BRAIN A JOURNAL OF NEUROLOGY Protection of primary neurons and mouse brain from Alzheimer’s pathology by molecular tweezers
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چکیده
Protection of primary neurons and mouse brain from Alzheimer’s pathology by molecular tweezers Aida Attar, Cristian Ripoli, Elisa Riccardi, Panchanan Maiti, Domenica D. Li Puma, Tingyu Liu, Jane Hayes, Mychica R. Jones, Kristin Lichti-Kaiser, Fusheng Yang, Greg D. Gale, Chi-hong Tseng, Miao Tan, Cui-Wei Xie, Jeffrey L. Straudinger, Frank-Gerrit Klärner, Thomas Schrader, Sally A. Frautschy, Claudio Grassi and Gal Bitan
منابع مشابه
Protection of primary neurons and mouse brain from Alzheimer's pathology by molecular tweezers.
Alzheimer's disease is a devastating cureless neurodegenerative disorder affecting >35 million people worldwide. The disease is caused by toxic oligomers and aggregates of amyloid β protein and the microtubule-associated protein tau. Recently, the Lys-specific molecular tweezer CLR01 has been shown to inhibit aggregation and toxicity of multiple amyloidogenic proteins, including amyloid β prote...
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